Safe Use of New technologies in Diabetes in Flight (SUNDIF)
Research type
Research Study
Full title
The effect of altitude and simulated flight in a hypobaric chamber on glucose metabolism and the in vivo performance of insulin delivery systems.
IRAS ID
319859
Contact name
David Russell-Jones
Contact email
Sponsor organisation
University of Surrey,
Duration of Study in the UK
1 years, 6 months, 1 days
Research summary
Atmospheric pressure can influence how the body handles blood glucose. At high elevations, atmospheric pressure decreases. Research shows that both the elevation and the length of stay at that elevation can influence the body’s glucose response.
We would like to find out if the change in pressure in the cabin environment during a flight affects the body’s handling of glucose. Commercial planes usually fly at 40000 feet (12192 m) but the cabin pressure is repressurised to 8000 feet (2438 m) with cabin pressure fixed at 560 mmHg. The normal atmospheric pressure at sea level is 760 mmHg. Since we cannot perform our studies in an aeroplane we will use a hypobaric chamber set to this low pressure which will reproduce the cabin environment during a commercial flight. The chamber is located at the research and development company, QinetiQ, MOD Boscombe.
The objective of this study is to compare the effect of atmospheric pressure on glucose metabolism during simulated flight conditions during fasting and in response to a mixed liquid meal.
This will involve attending three visits; visit 1 (screening), visit 2 and visit 4 and two phone visits. The duration of the study is 15 days or 1 month depending on the participant’s availability. Visit 1, informed consent and screening, will take place at CEDAR, Royal Surrey County Hospital, Guildford, followed by two visits of the meal test in random order at CEDAR or QintetiQ, Visit 2, will be a meal test performed at 760 mmHg OR at 560mmHg. Visit 4, will be a further meal test at 560 mmHg OR 760 mmHg. The order of the meal test visits at different ambient pressures will be randomised. The two phone visits will take place the day after the meal test days to enquire about the patient’s health after the test.REC name
West Midlands - Black Country Research Ethics Committee
REC reference
23/WM/0047
Date of REC Opinion
28 Feb 2023
REC opinion
Favourable Opinion