S-CORT: Stratification in COloRectal cancer:
Research type
Research Study
Full title
Stratification in COloRectal cancer: from biology to Treatment prediction (S-CORT)
IRAS ID
169363
Contact name
Timothy S Maughan
Contact email
Sponsor organisation
University of Oxford
Clinicaltrials.gov Identifier
Oxford REC A 10/H0604/72, R&D approval ref 6290., Oxford Endoscopy cohort; MREC/13/SC/0111, MRC FOCUS4 trial; 10/H0706/65, MRC ARISTOTLE trial; 79877428, MRC FOCUS trial; 04/MRE06/60, MRC COIN trial; MREC/03/9/053, MRC FOCUS2 trial; 04/4/015, RICE (NW-COG) trial; MREC/97/0/49, MRC CR07 trial; 01/12/2009, TREC trial; 09/H1010/75, UK collaboration; 09/H1010/75, UK consortium; 09/H1010/75, UK consortium/Oxford; 12/WA/0051, Copernicus
Duration of Study in the UK
4 years, 8 months, 31 days
Research summary
Colorectal cancer (CRC) is the 3rd most common cancer in the UK, with >40,000 new cases in 2011. While there have been improvements in CRC treatment, it remains a significant killer, with 16,000 deaths in 2011. Research by ourselves/others has revealed that a "one size fits all approach" will not work, as genetic changes in their CRC cells can cause treatments to fail in particular patients. This increased understanding has given rise to the concept of "stratified medicine", where testing a patient's sample prior to treatment can indicate which therapy works in this particular patient.
This "stratified" approach also allows patients who will not respond to be spared the often toxic side effects. Recognising the need to provide treatments leading to better survival/Quality of Life (Qol), a group of researchers, clinicians, patient groups and industry have formed a consortium (S-CORT), harnessing its members expertise to develop new approaches to stratify patients to improve outcomes, thus delivering real benefit for CRC patients.
This study will use samples which are either available from completed studies or to be collected from ongoing studies.REC name
East of England - Cambridge South Research Ethics Committee
REC reference
15/EE/0241
Date of REC Opinion
17 Jun 2015
REC opinion
Further Information Favourable Opinion