RUBI HF
Research type
Research Study
Full title
82-Rubidium Total Body Positron Emission Tomography for whole body organ perfusion in Heart Failure with Reduced Ejection Fraction
IRAS ID
357353
Contact name
Bashir Al-Hashimi
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
2 years, 9 months, 14 days
Research summary
Total body PET/CT is a recent development in imaging which allows for rapid, high quality, dynamic scans of the entire body. This is of particular interest in heart failure, which is known to have implications in other bodily systems such as the kidneys and nervous systems; indeed current treatment options for heart failure target these other systems. There is great interest to investigate these connections to understand how they interact and to allow for more targeted therapies. This study aims to elucidate the connections between these systems in a way that has not been possible prior to the advent of this new technology. We will achieve this by performing 20 scans of patients with reduced heart pumping function (heart failure with reduced ejection fraction, or HFrEF) related to ischaemic heart disease (where they are known to have impaired blood flow to the heart muscles). These will be compared with 20 scans from patients without these heart problems with the aim of assessing whether there are any changes to blood flow and metabolism in other organs in the body. This pilot study will allow us to find further avenues for investigating heart failure and its impact on, and from, other organ systems.
REC name
South East Scotland REC 02
REC reference
25/SS/0094
Date of REC Opinion
12 Dec 2025
REC opinion
Further Information Favourable Opinion