RRR Study
Research type
Research Study
Full title
Rupture and Re-intervention rates for distal aorta following Ascending/Root Repair for Type 1 Debakey Dissection in mid to long term (RRR study)
IRAS ID
329046
Contact name
Syed Waquar Yusuf
Contact email
Sponsor organisation
University Hospitals Sussex
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Aim(s) of the research: The purpose of the proposed research is to assess the rupture rate of the ballooned split segment of the untreated aorta, overall survival, and reoperation rates in the mid-term, following surgical treatment of acute Type-1 DeBakey Aortic dissection.
Background to the research: Acute aortic dissection (AAD) is a life-threatening medical emergency in which a tear occurs in the inner layer of the body’s main artery (aorta). Blood rushes through the tear, causing inner and middle layers of the aorta to split (dissect). It is associated with high death rates. The aortic dissections are classified into three types (type I, II, and III) according to the DeBakey classification. In type I dissection, tear starts where the aorta exits the heart extends into the abdomen. As part of our study we are interested in Type 1 only. This is an immediate life-threatening problem where primary repair involves, surgeon removing as much torn segment as possible and replacing it with synthetic tube (graft) to reconstruct the upper aorta irrespective of the extent of splitting process in the rest of the aorta. Despite initial lifesaving repair, the survivors continue to be at risk of future complications that may require very high risk intervention. There is limited data on the risk of rupture of the chronic dissection. We aim to investigate the mid to long-term outcome of these patients to gain a better understanding of the rupture risk.
Design and methods: The study involves obtaining data for all patients who underwent operative treatment for Type 1 Debakey dissection from National Institute for Cardiovascular Outcomes Research (NICOR) - where the National cardiac database is maintained. We will link the NICOR data to the Hospital Episode Statistics (HES) for information regarding readmission, re-operation and other relevant episodes.REC name
South East Scotland REC 02
REC reference
24/SS/0041
Date of REC Opinion
14 May 2024
REC opinion
Further Information Favourable Opinion