Rotigotine and Memory in Parkinson's.

• Research type

  Research Study

• Full title

  The Effect of Rotigotine on Memory in Idiopathic Parkinson's Disease without Cognitive Impairment

• IRAS ID

  141978

• Contact name

  Simon Ellis

• Contact email

  simon.ellis@uhns.nhs.uk (always put in "to" field, do not cc)

• Sponsor organisation

  University Hospital of North Staffordshire NHS Trust

• Eudract number

  2014-000335-17

• Research summary

  A lesser known aspect of Parkinson's is memory impairment. Whilst this may seem trivial compared to the motor dysfunction associated with Parkinson's, being unable to recollect people's names of people and places we know, and our previous experiences can lead to embarrassment, social isolation and depression. Research has previously reported recollection impairments in Parkinson's, but the role that Parkinson's medication plays in this impairment is under researched. A recent study of ours (Shepherd et al, 2013), compared how two D2 dopamine agonists (pramipexole and ropinirole) effected memory. We found that pramipexole use resulted in a memory impairment, whereas ropinirole did not. An alternative to the orally digested pramipexole and ropinirole is rotigotine which is a transdermal patch. This study aims to explore the effect that rotigotine has on memory in Parkinson's.

• REC name

  North West - Haydock Research Ethics Committee

• REC reference

  14/NW/1235

• Date of REC Opinion

  28 Oct 2014

• REC opinion

  Further Information Favourable Opinion