ROMEO

• Research type

  Research Study

• Full title

  Mechanical ventilation to accelerate recovery of lung function in veno-venous extracorporeal membrane oxygenation; lung Rest Or Moderate Mechanical ventilation in ECMO: randomized trial

• IRAS ID

  256932

• Contact name

  Luigi Camporota

• Contact email

  luigi.camporota@gstt.nhs.uk

• Sponsor organisation

  GSTT

• Duration of Study in the UK

  1 years, 6 months, 30 days

• Research summary

  The aim of ROMEO trial is to determine whether the delivery of mechanical ventilation based on the concept of ‘lung rest’: ultra-low frequency of respiratory movements (2 breaths per minute) for a minimum of three days of ECMO, increases functional lung recovery, compared to standard ventilation (15-30 breaths per minute) in patients on ECMO for acute severe hypoxaemic respiratory failure.
  In this study, the mean airway pressure is maintained and the time to ECMO decannulation as a surrogate outcome measure of recovery.
  

• REC name

  North West - Greater Manchester South Research Ethics Committee

• REC reference

  21/NW/0101

• Date of REC Opinion

  8 Jun 2021

• REC opinion

  Further Information Favourable Opinion