Role of Salt Supplementatiopn in Reflex Syncope
Research type
Research Study
Full title
Role of Salt Supplementatiopn in Reflex Syncope
IRAS ID
123034
Contact name
Amir Anwar
Contact email
Sponsor organisation
Central Manchester University Hospitals NHS Foundation Trust
Research summary
This project aims to study the role of salt supplementation to treat reflex syncope. This is an important factor as a cause of syncope. In the last few years, many groups investigating syncope have noted that the incidence of Reflex Syncope has been rising, and have reflected that the public health message has been taken too much to heart, and a lot of patients become salt and fluid depleted, resulting in poor volume reserves and an increased tendency to Reflex Syncope. Also noted previously is that patients tending to Reflex Syncope have high levels of resting arginine vasopressin - AVP, which further rise very high when these patients suffer orthostatic stress. We postulate that AVP/renal mechanisms are recruited to help maintain blood pressure in such patients. We plan to assess this with baseline AVP and 24hr sodium excretion, before giving patients salt-supplementation in the form of slow sodium tablets, and then repeat the estimation of AVP and 24hr sodium excretion.
REC name
North West - Preston Research Ethics Committee
REC reference
13/NW/0374
Date of REC Opinion
29 May 2013
REC opinion
Favourable Opinion