Role of FAAH-OUT gene in skin wound healing
Research type
Research Study
Full title
Investigating the mechanism of FAAH OUT micro deletion in wound healing
IRAS ID
278803
Contact name
Devjit Srivastava
Contact email
Sponsor organisation
NHS Highland
Duration of Study in the UK
0 years, 0 months, 3 days
Research summary
The goal of this research is to better understand the molecules and genes that control skin wound healing. Recently we reported the case of a unique individual who displays an exceptionally high tolerance for pain as well as accelerated cutaneous wound healing with reduced scarring. Sequencing of her DNA identified a genomic deletion of a genetic element known as FAAH-OUT. FAAH-OUT deletion along with a known SNP [Single nucleotide polymorphism] correlates to increased fatty acid amides and cannabinoid levels which is hypothesized to mediate increased pain tolerance,reduced anxiety and faster wound healing.\n However, this hypothesis has not been tested especially in relation to wound healing. The purpose of this study is to understand how the FAAH OUT deletion leads to improved skin wound healing by performing biochemical and genetic experiments on this unique individual’s skin tissues and cells. The potential benefit of this work is to generate new knowledge that can contribute to better wound healing therapies. Poor wound healing especially post surgery, is a major biomedical health burden, and improved treatments to treating wounds are needed.\n
REC name
South Central - Oxford B Research Ethics Committee
REC reference
22/SC/0216
Date of REC Opinion
22 Sep 2022
REC opinion
Further Information Favourable Opinion