RNA biomarkers of ageing within plasma samples.
Research type
Research Study
Full title
Identification of RNA biomarkers of ageing within plasma samples obtained from osteopenic women.
IRAS ID
292399
Contact name
Gayle Marshall
Contact email
Sponsor organisation
Medicine Discovery Catapult
Clinicaltrials.gov Identifier
ACTRN12609000593235, Australian New Zealand Clinical Trials Registry number
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
The UKSPINE Knowledge Exchange is a collaboration between Medicines Discovery Catapult, University of Dundee Drug Discovery Unit, University of Birmingham, University of Oxford and the Francis Crick Institute. The aim of this UK SPINE project is to improve health in old age, by accelerating the development of new and affordable therapies which overcome the generic processes driving ageing and age-related diseases.
As part of this collaboration, MDC have secured funding to carry out a biomarker profiling study on a range of samples of ageing to ultimately identify new drug targets of healthy and unhealthy ageing.
A key part of this study is identifying the best samples of ageing, which our collaboration partner University of Oxford have as part of a wider study carried out in New Zealand where bisphosphonates were explored to prevent fractures in patients suffering with osteopenia in combination with other risk factors, such as age. The plan is to screen up to 168 of these patient samples, investigating circulating mRNA expression to see if there are key pathways identified relating to age, in particular healthy ageing that can be progressed into a drug pipeline.
REC name
North East - Tyne & Wear South Research Ethics Committee
REC reference
21/NE/0081
Date of REC Opinion
13 Apr 2021
REC opinion
Favourable Opinion