Risk Stratification of Pulmonary Embolism
Research type
Research Study
Full title
Diagnostic Utility of 6-minute Walk Test and ABG in Suspected Low-Probability Pulmonary Embolism In Patients Presenting at Northwick Park Hospital
IRAS ID
324130
Contact name
Gothandaraman Balaji
Contact email
Sponsor organisation
Northwick Park Hospital
Duration of Study in the UK
0 years, 6 months, 30 days
Research summary
Pulmonary embolism (PE) is the third most common acute cardiovascular problem in the world. It is associated with high early mortality (up to 30%), which reduces to 8% if diagnosed and treated in a timely fashion. There are comprehensive criteria to stratify suspicion of PE. However, despite advancements in diagnosis and treatment of PE, many patients with low risk disease remain exposed to dangers of over-investigation, such as radiation exposure from CTPA (computed tomography pulmonary angiogram). This study aims to look at variations in oxygen levels in blood after 6-minute exertion and its reliability to safely exclude PE in patients with low-probability disease. This would reduce radiation exposure of patients with low-probability PE and could serve as a more cost-effective diagnostic tool.
REC name
South Central - Oxford A Research Ethics Committee
REC reference
24/SC/0068
Date of REC Opinion
8 May 2024
REC opinion
Further Information Favourable Opinion