Risk Reducing Breast Reconstruction Study
Research type
Research Study
Full title
A feasibility study to determine the effect of risk reducing mastectomy and breast reconstruction surgery on physical function, quality of life and activity.
IRAS ID
249291
Contact name
R D Macmillan
Contact email
Sponsor organisation
Nottingham University Hospitals NHS Trust
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
BRCA 1/2 are inherited genetic mutations which increase the risk of developing early-onset breast and ovarian cancer. The prevalence of BRCA mutations in the general population is currently estimated at 1/800 to 1/1000, for women this equates to approximately 1/250 risk of either gene mutation. Women with an inherited BRCA1 mutation have a lifetime risk of 65–80% of developing breast cancer and 37–62% of developing ovarian cancer, while BRCA2 mutation carriers have a lifetime risk of 45–85% for breast cancer and 11–23% for ovarian cancer.
Women who are diagnosed with a BRCA mutation at NUH are given the option to be referred for genetic counselling, breast screening and breast surgery. Currently, approximately 65 women per year are diagnosed as BRCA positive at NUH.
This research project is only concerned with the increased breast cancer risk associated with BRCA 1/2 mutations and the subsequent breast surgery care pathway. Women who are BRCA1/2 positive may elect to have risk-reducing breast surgery. There are a number of breast surgery options available to women at NUH opting for elective surgery.
There is very little literature available assessing the outcomes of risk reducing patients undergoing each type of surgery. This study aims to better understand the effect these different types of risk reducing breast reconstruction have on function, quality of life and physical activity level.REC name
South Central - Oxford C Research Ethics Committee
REC reference
18/SC/0694
Date of REC Opinion
10 Jan 2019
REC opinion
Further Information Favourable Opinion