Risk factors for the development of S aureus and E coli bacteraemias
Research type
Research Study
Full title
Case control study to identify the risk factors for the development of S.aureus and E. coli bacteraemias within NHS Scotland
IRAS ID
163388
Contact name
Alistair Leanord
Contact email
Sponsor organisation
NHS Greater Glasgow and Clyde
Duration of Study in the UK
1 years, 7 months, 27 days
Research summary
Bacteraemia (blood stream infection) causes a sizable amount of illness and death in the Scottish population. During the past five years, there has been a substantial reduction in MRSA (methicillin resistant Staph aureus) bloodstream infections, however, despite efforts directed towards reducing all S. aureus infections, the reduction in methicillin sensitive Staph aureus bloodstream infections has not been as marked. Likewise there has been an increase in the numbers of E coli bloodstream infections over the last four years. Both these infections cause significant mortality; between 15-30% of patients will die from their infection. The reasons for these changes are unclear. Using existing routinely collected data from National datasets it is proposed, using case control study methodology, to investigate what clinical markers are associated with an increased risk of onset of S. aureus bacteraemia or E. coli bacteraemia. This is a dual organism project as the data linkage can capture both organisms in a cost efficient manner, the methodology, study design, and skill set required for analysis are similar for each organism. The output will directly influence the development of prevention strategies for these infections.
REC name
South East Scotland REC 01
REC reference
15/SS/0179
Date of REC Opinion
2 Oct 2015
REC opinion
Favourable Opinion