Risk Evaluation in Ectopic Pregnancy (REEP)

• Research type

  Research Study

• Full title

  Serum Progesterone and hCG as Predictors for Expectant Management in Ectopic Pregnancy

• IRAS ID

  358786

• Contact name

  Nishel Shah

• Contact email

  nishel.shah@imperial.ac.uk

• Sponsor organisation

  Chelsea and Westminster NHS Foundation Trust

• Duration of Study in the UK

  2 years, 2 months, 31 days

• Research summary

  Ectopic pregnancy is a potentially life-threatening condition, but selected cases can be managed expectantly if the likelihood of spontaneous resolution is high. Currently, hCG dynamics guide management decisions, yet outcomes remain variable. Progesterone, a marker of corpus luteum function and early pregnancy viability, may provide complementary predictive value. This study aims to assess whether baseline serum progesterone and/or hCG levels can reliably identify patients likely to have successful expectant management, using retrospectively collected clinical data.

• REC name

  Wales REC 4

• REC reference

  25/WA/0271

• Date of REC Opinion

  17 Sep 2025

• REC opinion

  Favourable Opinion