Risk assessment for PTBD +/- stenting
Research type
Research Study
Full title
Risk stratification scoring for percutaneous transhepatic biliary drainage (PTBD), with or without stenting.
IRAS ID
141791
Contact name
Raman Uberoi
Contact email
Sponsor organisation
Oxford University Hospitals NHS Foundation Trust
Research summary
Research Summary
Patients who have bile duct obstruction can develop jaundice (yellowing of the skin and eyes), itching, pain and are at high risk of infections that can give flu-like symptoms. Some of these patients will need to go on and have drainage of the bile ducts via the skin, in a procedure called percutaneous biliary drainage (PTBD). The procedure (PTBD), however, carries with it a significant risk of death (1 in 5) or injury.
In this study we are attempting to find out which pre-procedure markers can be used to identify patients who are at higher than normal risk from the procedure itself. These markers include any pre-existing disease such as diabetes and abnormal blood test results.
Information will be collected on a form that will be filled out by an appropriate member of staff on the day of the procedure and again at day 7 and day 30. Once the information is collected, those patients who suffered significant injury or death from the procedure itself will be compared to those who came through with ease to see if there is any correlation between their outcome and their pre-procedure health.
By studying the link we hope to be better able to advise patients on their level of risk and to better enable radiology doctors to select patients who are likely to benefit from PTBD.
Summary of Results
This was an observational study looking outcomes of patients undergoing drainage for blocked bile ducts, to identify potential risk factors for poor outcomes. This study identified that several blood test parameters and a score of overall 'functional status' could help predict adverse outcomes from this procedure.
REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
14/LO/1131
Date of REC Opinion
25 Jun 2014
REC opinion
Further Information Favourable Opinion