RIPCa
Research type
Research Study
Full title
Remote ischeamic preconditioning in colorectal cancer surgery - a pilot study.
IRAS ID
243707
Contact name
Matthew Dickinson
Contact email
Sponsor organisation
Royal Surrey County Hospital NHS Trust
Clinicaltrials.gov Identifier
TBC, ISRCTN
Duration of Study in the UK
1 years, 6 months, 21 days
Research summary
During surgery the body goes through physiological changes that put it under stress and require the presence of adequate blood flow in order to avoid the development of complications. Previous studies have shown that if the blood flow to an arm is briefly reduced (like when a blood pressure cuff is inflated), then the stress to the body is less and the complications are reduced. This technique is called remote ischaemic preconditioning or RIPC. These studies have been done mainly in cardiac surgery. There are a few studies using RIPC in cancer surgery but none in colorectal cancer.
Patients who are scheduled to undergo surgery for colorectal cancer and who are at increased risk of developing complications after their operation will be invited to take part in the study. Following induction of general anaesthesia, the patients will be randomly allocated to either RIPC or standard group. The patients in the RIPC group will have a blood pressure cuff around one of their arms inflated 3 times for 5 minutes at a time followed by a 5-minute deflation. The patients in the standard group will not undergo this cuff inflation and deflation. Before and after RIPC, we will collect blood and urine samples that will be used for measurement of markers of kidney function (urinary biomarkers) and blood flow to the heart (troponin). All patients will be monitored for the development of complications such as infection, bleeding, heart or kidney failure during hospital stay and then via telephone at 1, 3 and 6 months after the operation. The kidney function will also be assessed via a blood test during the routine follow up 6 weeks after the operation.
If the study shows improvement in patient outcomes, RIPC will offer an easily implemented and inexpensive way to reduce complications associated with surgery.
REC name
London - Fulham Research Ethics Committee
REC reference
18/LO/1513
Date of REC Opinion
26 Oct 2018
REC opinion
Further Information Favourable Opinion