This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.

RIC-PREVENT

  • Research type

    Research Study

  • Full title

    Remote Ischaemic Conditioning for secondary prevention post stroke

  • IRAS ID

    272399

  • Contact name

    Ali Ali

  • Contact email

    ali.ali@sth.nhs.uk

  • Sponsor organisation

    Sheffield Teaching Hospitals

  • Duration of Study in the UK

    1 years, 6 months, 6 days

  • Research summary

    A quarter of all strokes are recurrent and are associated with greater disability. Despite optimal secondary prevention (antithrombotic, lipid lowering therapy, antihypertensive, lifestyle modification) rates of secondary vascular events remain high; 11.1% at one year in a recent systematic review (Mohan et al 2011). Previous research has shown that 300 days of bilateral arm RIC reduced rates of recurrent stroke from 26.7% to 7.9% in patients with intracranial artery stenosis (Meng et al 2012), however, no study has further evaluated the potential secondary preventative role of RIC after stroke or explored the biological mechanisms for this.\nThis is the first such study to investigate the secondary preventative use of RIC in stroke patients with and without intracranial arterial stenosis, as well as in patients with TIA. Further, we will explore whether a shorter period of RIC (8 weeks) delivered independently by the patient at home using a manual sphygmomanometer, may indicate a protective response. \n\nThis is a single centre pilot, randomised controlled study; the participants will receive either RIC or sham intervention for 8 weeks. Safety, acceptability, compliance to the intervention and the feasibility of the study will be assessed, via adverse event reporting, patient monitoring diaries, recruitment figures and completeness of follow up assessments. The combined endpoint of recurrent stroke, myocardial infarction, cardiac arrest, hospitalisation or death due to vascular causes will be compared statistically between CRIC and sham treatment arms to provide an estimate of effect size for informing the design / sample size of a future definitive study.\n

  • REC name

    South West - Frenchay Research Ethics Committee

  • REC reference

    19/SW/0215

  • Date of REC Opinion

    28 Nov 2019

  • REC opinion

    Further Information Favourable Opinion