RIC-PREVENT
Research type
Research Study
Full title
Remote Ischaemic Conditioning for secondary prevention post stroke
IRAS ID
272399
Contact name
Ali Ali
Contact email
Sponsor organisation
Sheffield Teaching Hospitals
Duration of Study in the UK
1 years, 6 months, 6 days
Research summary
A quarter of all strokes are recurrent and are associated with greater disability. Despite optimal secondary prevention (antithrombotic, lipid lowering therapy, antihypertensive, lifestyle modification) rates of secondary vascular events remain high; 11.1% at one year in a recent systematic review (Mohan et al 2011). Previous research has shown that 300 days of bilateral arm RIC reduced rates of recurrent stroke from 26.7% to 7.9% in patients with intracranial artery stenosis (Meng et al 2012), however, no study has further evaluated the potential secondary preventative role of RIC after stroke or explored the biological mechanisms for this.\nThis is the first such study to investigate the secondary preventative use of RIC in stroke patients with and without intracranial arterial stenosis, as well as in patients with TIA. Further, we will explore whether a shorter period of RIC (8 weeks) delivered independently by the patient at home using a manual sphygmomanometer, may indicate a protective response. \n\nThis is a single centre pilot, randomised controlled study; the participants will receive either RIC or sham intervention for 8 weeks. Safety, acceptability, compliance to the intervention and the feasibility of the study will be assessed, via adverse event reporting, patient monitoring diaries, recruitment figures and completeness of follow up assessments. The combined endpoint of recurrent stroke, myocardial infarction, cardiac arrest, hospitalisation or death due to vascular causes will be compared statistically between CRIC and sham treatment arms to provide an estimate of effect size for informing the design / sample size of a future definitive study.\n
REC name
South West - Frenchay Research Ethics Committee
REC reference
19/SW/0215
Date of REC Opinion
28 Nov 2019
REC opinion
Further Information Favourable Opinion