Rhematoid Arthirits and Muscle - RAMUS study

• Research type

  Research Study

• Full title

  An observational , single-arm study of skeletal muscle metabolism in patients with rheumatoid arthritis receiving Tofacitinib

• IRAS ID

  266288

• Contact name

  Aaron Jackson

• Contact email

  aaron.jackson@nhs.net

• Sponsor organisation

  Newcastle upon Tyne Hospitals NHS Trust

• Duration of Study in the UK

  1 years, 11 months, 31 days

• Research summary

  This trial studies the role of the drug Tofacitinib in the reversal of the skeletal muscle loss, sarcopenia, that occurs in Rheumatoid Arthritis patients. It has the potential to contribute work of significant improvement in our understanding of sarcopenia, and provide targeted future therapy that's beyond reversal of joint inflammation. Patients with active Rheumatoid Arthritis treated with tofacitinib would undergo various investigations of muscle structure and function before and during treatment. This will take place over a period of 6 months.Potential participants will be identified and recruited at routine out-patient clinics at the Freeman Hospital. Patient identification may be extended to Patient Identification Centres (PIC sites) at surrounding hospitals.

• REC name

  South East Scotland REC 01

• REC reference

  19/SS/0100

• Date of REC Opinion

  16 Sep 2019

• REC opinion

  Favourable Opinion