REVIVE-TR
Research type
Research Study
Full title
Right Ventricular Remodelling Following Transcatheter Tricuspid Valve Intervention: A UK Multi-Centre Observational Imaging Study
IRAS ID
369914
Contact name
Alison Duncan
Contact email
Sponsor organisation
Guy’s and St Thomas’ NHS Foundation Trust (Royal Brompton Hospital)
Duration of Study in the UK
0 years, 9 months, 9 days
Research summary
Tricuspid regurgitation is a condition where the tricuspid heart valve leaks, causing blood to flow backwards and placing strain on the right side of the heart. It is well known to cause symptoms such as shortness of breath, fatigue and fluid retention, and is associated with significant health problems, including repeated hospital admissions and reduced survival.
Two main keyhole treatments are now used. One clips the valve leaflets together to reduce the leak (transcatheter tricuspid edge-to-edge repair, T-TEER) and the other replaces the valve using a catheter (transcatheter tricuspid valve replacement, TTVR). Both approaches have been shown to reduce tricuspid regurgitation effectively and improve symptoms in many patients. However, it is still not well understood how these procedures affect the heart muscle itself, particularly the right ventricle, which may already be stretched and weakened by long-standing valve leakage. In some patients, early measurements of right-ventricular function appear to worsen after the procedure, and we do not yet know how often this happens, whether it is temporary, or which patients are most likely to recover.
This study will use echocardiograms (heart ultrasound scans) already performed as part of routine NHS care to understand how the right ventricle changes after transcatheter tricuspid valve intervention. We will collect scans from several UK centres and analyse them centrally at Royal Brompton Hospital using standardised methods, including advanced measurements of right-heart size and function (such as right-ventricular volumes and right-ventricular strain). We will compare scans taken before treatment, shortly after the procedure (where available), and at follow-up, especially at 3 to 6 months (and 12 months where available).
No patients will be contacted and no extra hospital visits, tests or scans are required. Data will be pseudonymised before transfer for analysis, and strict information governance procedures will be followed. The findings will help clinicians understand recovery patterns, improve patient selection and timing of treatment, and guide follow-up care after transcatheter tricuspid procedures.
REC name
London - Surrey Borders Research Ethics Committee
REC reference
26/LO/0290
Date of REC Opinion
17 Apr 2026
REC opinion
Favourable Opinion