REVITALiSE
Research type
Research Study
Full title
Randomised evaluation platform – Interventions to treat older people with sarcopenia
IRAS ID
352708
Contact name
Miles Witham
Contact email
Sponsor organisation
Newcastle upon Tyne Hospitals NHS Foundation Trust
Duration of Study in the UK
2 years, 9 months, 30 days
Research summary
Muscle weakness in older people (known as sarcopenia) is common and can lead to falls, problems with mobility and the ability to look after oneself, poorer quality of life, longer hospital stays and earlier death. REVITALiSE will test different ways of treating muscle weakness in older people using a ‘platform trial’ design.
We will identify people aged 65 and over from GP practices, hospital clinics, registries and previous studies. We will do a brief telephone call (prescreening call) to check whether the person is likely to be eligible to take part, and if they are, we will do a full screening visit in their own home or in the research centre. Where participants are eligible for more than one subtrial (once more than one subtrial is running) we will give them the choice of which one they wish to take part in.We will measure all participants' balance, walking speed and muscle strength. We will measure muscle size throughout the body using a scan called a DXA scan. We will also take a blood sample and a small sample of muscle from the thigh (a muscle biopsy). These tests will be performed at the beginning of the trial.
We will randomise participants to get 12 weeks of treatment (each subtrial will have a different treatment) or 12 weeks of usual care. At the end of this period, we will repeat all the measures. Each subtrial will recruit approximately 30-40 participants, depending on the treatment being tested.
REC name
North East - Tyne & Wear South Research Ethics Committee
REC reference
25/NE/0115
Date of REC Opinion
4 Jul 2025
REC opinion
Favourable Opinion