Revision Hip & Knee Replacement: Evaluation of Multimodal Outcomes
Research type
Research Study
Full title
Revision Hip and Knee Replacement: Evaluation of Clinical, Psychological and Surgical Outcomes
IRAS ID
278592
Contact name
Andrew Price
Contact email
Sponsor organisation
University of Oxford / Clinical Trials and Research Governance
Duration of Study in the UK
8 years, 0 months, 1 days
Research summary
Hip and knee replacement implants are designed to last a long time, but they do not last forever. A revision joint replacement is a procedure to replace an implant that is no longer functioning correctly. These procedures are major surgery because performing a joint replacement can be much more complicated the second (or third) time. This may be due to the presence of infection or formation of scar tissue and loss of bone over time.
Around 13,000 revision operations are performed each year in the United Kingdom at a cost of up to £200 million. The majority of these procedures are successful and many – such as those for infection or fracture – cannot be avoided. However, other revision procedures are discretional and depend on a discussion of risks versus benefits between a patient and their surgeon. In the discretional group, up to one-in-three patients who undergo revision surgery do not experience any benefit and the reasons for this are not well understood.
This study will analyse anonymized data from several sources within the NHS that routinely collect information related to revision joint replacement. We will analyse data on patient satisfaction from Patient Reported Outcome Measures; hospital admissions from Hospital Episode Statistics; joint replacements from the National Joint Registry; and mortality from the Office for National Statistics.
We will analyse this data to describe patient satisfaction and function after revision surgery, medical risks, and the need for further surgery and identify the factors that underpin each of these.
This proposal will provide new evidence to allow patients to fully participate in the decision as to whether or not to undergo revision surgery. It will create clinical guidelines to support surgeons and will guide improvements in the revision hip and knee replacement pathway.
REC name
London - Bromley Research Ethics Committee
REC reference
20/LO/0428
Date of REC Opinion
2 Apr 2020
REC opinion
Favourable Opinion