Reversible Myocardial Dysfunction in the Critically Ill
Research type
Research Study
Full title
Evaluation of the time course of acute, reversible myocardial dysfunction in the general adult intensive care population
IRAS ID
134971
Contact name
Victoria Trubody
Contact email
Research summary
This study aims to describe the time course of reversible heart function in patients experiencing critical illness. It is
known that a reversible heart impairment can occur in patients with certain types of critical illness, such as severe
infections. Little is known about how this condition may affect other types of patients admitted to Intensive Care, or if the
results seen in patients with infections are applicable to other groups.
We wish to use both ultrasound (echocardiography) and cardiac magnetic resonance imaging (CMRI) to look at in
detail any changes in, and the recovery of, heart function during critical illness. Whilst participants are admitted to the
Intensive Care Unit, we wish to assess changes in heart function using bedside echocardiography. When some of
these participants have been discharged to the wards, and are medically stable, we wish to use CMRI to add further,
highly detailed, information about the recovery of the heart following critical illness.
Finally, in participants who demonstrate impaired heart function whilst in hospital and who are not receiving certain
heart medications (e.g. noradrenaline), we wish to take a small blood sample at the time of heart assessments to see
if the reversible heart impairment seen in critically ill patients share common features with other reversible heart
conditions (elevated stress hormones).
This study will assess the changes in heart function during the course of, and recovery from, critical illness. We wish to
study a total of 60 patients over the next year. The study will be conducted at Oxford University Hospitals NHS Trust,
funded by the Nuffield Department of Clinical Neurosciences, University of Oxford.REC name
South Central - Berkshire Research Ethics Committee
REC reference
14/SC/0305
Date of REC Opinion
26 Jun 2014
REC opinion
Favourable Opinion