Retrospective OA review

• Research type

  Research Study

• Full title

  Does antacid type medication reduce the incidence of anastomotic stricture following repair of oesophageal atresia?

• IRAS ID

  180112

• Contact name

  Nigel Hall

• Sponsor organisation

  University Hospital Southampton NHS Foundation Trust

• Duration of Study in the UK

  0 years, 11 months, 30 days

• Research summary

  Oesophageal atresia (OA) with or without Trache-Oesophageal Fistula (TOF) affects approximately 1 in 3000 newborn infants. Following surgical correction there are a number of potential complications of this surgery, most significantly anastomotic leakage and anastomotic stricture. Anastomotic stricture is reported to occur in approximately 30% of infants and is most commonly treated by dilatation of the stricture. Some infants require multiple episodes of dilatation. Anastomotic stricture has recently been identified as a particularly key factor for parents. In order to try to reduce the incidence of post-operative structure some surgeons have proposed routine treatment of infants with OA with antacid type medications. This is based on the premise that there is a high incidence of gastro-oesophageal reflux (GOR) following surgical correction of OA and that GOR is known to be a risk factor for oesophageal structure formation even in the absence of OA. There are potential detrimental effects of antacid medication.
  We aim to review our recent experience of treating babies with OA. In particular we will investigate whether there is evidence that antacid medication influences the incidence of stricture and compare our single centre outcomes with those reported in the recent literature.

• REC name

  Wales REC 7

• REC reference

  15/WA/0153

• Date of REC Opinion

  29 Apr 2015

• REC opinion

  Favourable Opinion