Retro Pro Panc Study Version 1.3
Research type
Research Study
Full title
Long term consequences of pancreatic resection: retrospective and prospective analysis of outcomes.
IRAS ID
288252
Contact name
Mary E Phillips
Contact email
Sponsor organisation
University of Surrey
Duration of Study in the UK
4 years, 0 months, 1 days
Research summary
This project observes patients who have had an operation on their pancreas to identify the long-term consequences of this surgery. Surgery to the pancreas is complicated and affects many of the digestive pathways in the body. Specifically, digestive enzyme production is reduced, and the first part of the small bowel, where many nutrients are absorbed, is removed. The new joins within the bowel mean there is poor mixing of other digestive fluids, and there is the potential for this to alter the bacteria within the gut.
The aim of this study is to identify the frequency of complications and the impact this has on quality of life. Subdivision of data will help identify if there are predisposing factors that explain the variation of impact and help identify risk factors for long term complications.
Patients can be recruited at any stage before or after their operation, which is only carried out at specialist pancreatic centres. Those recruited before their operation will be asked to consent to ultrasound measurement of their leg muscles before and after their surgery and to wear a wrist watch style activity monitor for 6 weeks, to assess how quickly their ability to exercise recovers.
All patients will be asked to complete questionnaires annually for 4 years assessing quality of life, activity levels and which foods they consume.
Consent will be sought for access to the results of tests undertaken as part of clinical management, including blood test and scan results, body weight and strength measurements (grip strength). Scan results will be retrospectively analysed to measure muscle mass. Consent will also be requested for access to cause of death, should this be necessary.
Data from this study will be used to identify what follow up patients need after surgery, and to support further prospective research in this field.REC name
London - Surrey Research Ethics Committee
REC reference
21/LO/0139
Date of REC Opinion
4 Mar 2021
REC opinion
Further Information Favourable Opinion