RETRO-CHOP
Research type
Research Study
Full title
A retrospective translational study: Characterisation of molecular predictors of outcome in patients with diffuse large B cell lymphoma treated on the R-CHOP14 vs 21 multicentre trial
IRAS ID
169199
Contact name
David Cunningham
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
Version 8.0; 19/10/2012; REC number 07/Q0501/49, R-CHOP14 vs 21 trial
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
This is a retrospective study which aims to perform biomarker analyses on archived samples from patients with diffuse large B cell lymphoma (DLBCL) who have been treated on the R-CHOP14 vs 21 multicentre trial between 2005 and 2008. This will include all trial patients who have donated their tissue for research purpose and have tumour tissue available.
This study will evaluate the incidence and the predictive/prognostic value of several biomarkers and will provide a valuable platform to complement ongoing translational studies on the R-CHOP14 vs 21 study cohort. Assessment of DNA methylation and mutations are currently the main focus of this study, but other biomarkers including (but are not limited to) DNA copy number changes, gene expression profiling and metabolites may be considered for analysis.
REC name
South Central - Berkshire Research Ethics Committee
REC reference
15/SC/0049
Date of REC Opinion
14 Jan 2015
REC opinion
Favourable Opinion