Retinal vessel oxygenation and retinal nonperfusion
Research type
Research Study
Full title
A prospective observational study evaluating retinal vessel oxygenation using non-invasive oximetry and its relationship with retinal nonperfusion in patients with retinal vascular diseases.
IRAS ID
159876
Contact name
Luke Nicholson
Contact email
Sponsor organisation
University College London
Duration of Study in the UK
1 years, 6 months, 7 days
Research summary
Retinal vascular diseases such as diabetic retinopathy and retinal vein occlusion are the commonest retinal vascular diseases. Retinal nonperfusion is believed to be the main risk factor for developing complications related to these diseases.
The primary objective is to explore the relationship of areas of retinal nonperfusion with oxygen measurement of retinal blood vessels, specifically the difference in oxygenation of the artery and vein, the aterio-venous difference (AV difference) using a non-invasive method. The AV difference should reflect oxygen consumption in the retina. By establishing a relationship, we can estimate retinal nonperfusion with a fast and non invasive method.
The main secondary objectives are to observe the changes in AV difference following treatment with laser and anti-VEGF injections and to evaluate the AV difference and its relationship with retinal thickness of areas of nonperfused retina and retinal function.
We wish to study consenting adult patients with diabetic retinopathy, retinal vein occlusion and other retinal vascular diseases. The study will be conducted in Moorfields Eye Hospital. Most patients will require a single visit for the noninvasive tests. A proportion of patients in the secondary objective evaluating change following treatment will require a second visit for similar investigations. The tests will take 45 minutes to complete. Tests will be performed during other pre-existing appointments to the hospital for patient convenience. It involves three safe, risk free and non invasive imaging tests on the eye. We plan to complete the study over an 18 month period.REC name
Wales REC 6
REC reference
14/WA/1224
Date of REC Opinion
12 Nov 2014
REC opinion
Further Information Favourable Opinion