Retinal vascular insights into Fibromuscular Dysplasia
Research type
Research Study
Full title
Dynamic retinal vascular analysis to unlock the pathophysiology of fibromuscular dysplasia
IRAS ID
345558
Contact name
Hala Shokr
Contact email
Sponsor organisation
University of Manchester
Duration of Study in the UK
4 years, 0 months, 0 days
Research summary
Fibromuscular Dysplasia (FMD) is a rare vascular disease primarily affecting medium-sized arteries mostly in young to middle-aged women, comprising up to 10% of global renal artery narrowing cases. It often involves multiple arteries and can lead to severe complications.
A significant challenge in managing FMD is its frequent under or misdiagnosis, with an incidental prevalence and an average diagnosis delay of 4-9 years. The current diagnostic gold standard is invasive and poses risks due to the vulnerability of FMD-affected arteries to tearing during the procedure.
Until now we don't understand the cause of the disease or why it affects arteries and people differently.
This study aims to analyse differences in the function and structure of microvessels (small vessels) between patients with FMD and those without, using a non-invasive examination of the small vessels at the back of the eyes. Since changes in small vessels are known to precede the clinical manifestations of the disease, this approach will enhance understanding of the underlying causes of FMD. Additionally, it may provide a non-invasive method for monitoring disease progression and evaluating patient responses to treatment.REC name
South West - Frenchay Research Ethics Committee
REC reference
25/SW/0043
Date of REC Opinion
15 May 2025
REC opinion
Further Information Favourable Opinion