RetICS Study v.2.0
Research type
Research Study
Full title
Is Pre-operative Reticulocyte Haemoglobin Content associated with Post-operative Outcomes following Cardiac Surgery?
IRAS ID
246925
Contact name
Manraj Sandhu
Contact email
Sponsor organisation
South Tees Hospitals NHS Foundation Trust
Duration of Study in the UK
0 years, 3 months, 30 days
Research summary
Previous studies have shown that about 20-30% of people are anaemic (have a low blood count) before heart surgery and this will mean a worse outcome (longer length of stay in hospital, an increase in risk of death and an increase in risk of blood transfusion). A low blood count is often related to a low iron levels (iron deficiency) or not using iron appropriately (functional iron deficiency). More recently, it has been shown that a regulator of iron levels (hepcidin) is related to worse outcomes after heart surgery. This regulator is also increased in response to inflammation in the body. People that have heart attacks have a form of inflammation.
This study aims to observe if a blood test is related to post-operative outcomes after heart surgery. The blood test is called reticulocyte haemoglobin content - this measures how well iron is added to a red blood cell. Red blood cells carry oxygen around the body. This marker puts together both low levels of iron in the blood and problems with inappropriate under use of iron.We want to take a sample of blood before a participant has their heart operation and collect data on their stay.
The post-operative outcomes would include: a participant's requirement for a transfusion of blood, their length of stay in hospital and complications they may suffer. We would look to recruit people having any heart surgery.
REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
19/EM/0084
Date of REC Opinion
15 May 2019
REC opinion
Further Information Favourable Opinion