Resuscitation optimisation study
Research type
Research Study
Full title
Optimisation of tidal volumes during resuscitation at birth
IRAS ID
226008
Contact name
Charles Christoph Roehr
Contact email
Sponsor organisation
University of Oxford
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Preterm birth (<37 weeks of gestation) is a significant cause of childhood morbidity and mortality, as it is estimated that one million children worldwide die each year of complications of prematurity. Respiratory support at birth is needed in a large proportion of preterm infants, in the form of intermittent positive pressure ventilation, to support the transition from fluid filled lungs to air breathing. Studies have shown that resuscitation is more effective with volume and pressure monitoring and targeted limits of tidal volume can be achieved with the use of respiratory function monitors. At present, there is no tidal volume monitoring during resuscitation of preterm infants in routine neonatal clinical practice, in our unit. We aim to measure the expiratory tidal volume (TV) delivered during resuscitation at birth in preterm babies born between 23 and 32 weeks of gestation at tertiary neonatal center, with the use of respiratory function monitor. We will assess the proportion of babies who receive abnormally high (>8 ml/kg) or abnormally low TV (<4ml/kg) and we will compare the measured tidal volumes with the optimal tidal volumes, calculated on the basis of birth weight. We will assess the main respiratory and neurological outcomes in relation to tidal volumes during resuscitation.
REC name
South Central - Oxford A Research Ethics Committee
REC reference
18/SC/0097
Date of REC Opinion
5 Apr 2018
REC opinion
Further Information Favourable Opinion