Resuscitating Heart Transplantation Version 1
Research type
Research Study
Full title
Reconditioning the donor heart using ex-situ normothermic machine perfusion (ES-NMP)
IRAS ID
248479
Contact name
Stephen Large
Contact email
Sponsor organisation
Royal Papworth Hospital
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Heart transplantation from Donation After Circulatory determined Death (DCD) donors has recently been shown to increase overall heart transplant activity by 40% at Royal Papworth Hospital with outcomes equivalent to hearts transplanted from donors where death has been confirmed by neurological criteria. Unfortunatley the programme has failed to attract government funding due to the high cost of the consumables for the portable ex-situ perfusion machine. This current machine in addition to cost has several other limitations which prevent paediatric DCD heart donation. In response to these challenges Royal Papworth Hopsital have developed a machine capable of normothermic ex-situ machine perfusion of DCD donor hearts which we wish to evaluate on human DCD donor hearts that are currently not suitable for transplantation.
REC name
East of England - Cambridgeshire and Hertfordshire Research Ethics Committee
REC reference
18/EE/0303
Date of REC Opinion
22 Feb 2019
REC opinion
Further Information Favourable Opinion