RESTED
Research type
Research Study
Full title
Remote Evaluation of Sleep To enhance understanding of Early Dementia
IRAS ID
266809
Contact name
Jonathan Blackman
Contact email
Sponsor organisation
University of Bristol
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Promoting physiological processes during sleep holds great promise to improve brain health in later life. Our overarching goal is to refine the treatment of dementia-related sleep and memory impairment.
There are estimated to be 850000 people living with dementia in the UK alone where it is recognised as the leading cause of death . These numbers are forecast to rise by 35% by 2025 and 146% by 2050. As well as the human cost, financially dementia is estimated to cost approximately £26bn per year . Alzheimer’s Disease (AD) is the most common form of dementia accounting for approximately two thirds of all cases in the UK . After AD, the second most common neurodegenerative dementia is Lewy Body Dementia (LBD) , encompassing both Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) . There are no current treatments for dementia that delay progression and new approaches are desperately needed. This work will focus on both AD and LBD, together with their prodromal stages of Mild Cognitive Impairment (MCI).
This study programme has four major themes, united by the need for sleep and activity data collection in older people including those who present to cognitive clinic. The work is funded by Above and Beyond charity, BRACE charity and Alzheimer’s Research UK and there are great efficiencies in combining these 4 themes as the related projects recruit the same cohort and use similar technology and assessments to answer different questions. Therefore we have developed the RESTED Programme and will invite healthy controls, alongside participants with AD, LBD and DRD to undergo a combination of sleep monitoring at home and specific tests of cognition over a medium term.
REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
21/YH/0177
Date of REC Opinion
13 Sep 2021
REC opinion
Further Information Favourable Opinion