Respired gases in patients post cardiac surgery, version 1.0
Research type
Research Study
Full title
An observational study of the relationship between respired gases and mixed venous oxygen content and cardiac output in mechanically ventilated patients post cardiac surgery
IRAS ID
306400
Contact name
Don Tishan Wellalagodage
Contact email
Sponsor organisation
Research Services | Research Governance, Ethics & Assurance Team University of Oxford
Clinicaltrials.gov Identifier
000000, Details of the study will be available on HRA research summaries
Duration of Study in the UK
1 years, 11 months, 31 days
Research summary
The broad objective of this prospective, observational study is to gain a better understanding of the relationship between respired gas and cardiac output/mixed venous oxygen saturation. The opportunity to examine this area more closely than has previously been possible, arises from the development of technology to make highly precise measurements of respiratory exchange non-invasively in these patients: the Optical Gas Analyser (OGA).
The gas analyser will be used to measure respired gas flow concurrently alongside real-time cardiac output measurements, with the use of a pulmonary artery catheter, to examine the effect of various interventions employed as part of routine cardiothoracic intensive care.
Recruitment will last 2 years. Adult (18+) patients set to undergo cardiac surgery will be identified in pre-assessment clinic or during their outpatient clinic visit with the surgeon and asked if they would like to participate in the study. Not all patients will be included in the study. If agreeable, they will be handed a patient information sheet, included in the study and consented on the day of their admission to hospital. No additional visits are necessary. Once the participant is admitted to cardiothoracic intensive care following the surgery, we will use the gas analyser for what will typically be a period of 2-4 hours. The analyser will be incorporated into the breathing circuit.
To allow the gas analyser to acquire certain physiological data during the study it will be necessary to slightly vary the tension of oxygen and carbon dioxide for short periods (1-5 min). The changes involved will be of a lesser magnitude than those often seen due to natural variation over time in critically ill patients.
Clinical decisions will be made as per standard operating procedures, there will be no regard for measurements derived from the gas analyser.REC name
West Midlands - Black Country Research Ethics Committee
REC reference
22/WM/0094
Date of REC Opinion
4 May 2022
REC opinion
Favourable Opinion