Respiratory function in early onset scoliosis
Research type
Research Study
Full title
Assessment of Respiratory Function in Early Onset Scoliosis (a feasibility study)
IRAS ID
249650
Contact name
Lee Breakwell
Contact email
Sponsor organisation
Sheffield Children's NHS Foundation Trust
Duration of Study in the UK
0 years, 6 months, 0 days
Research summary
Children with early onset scoliosis (EOS) can experience significant curves of the spine which are associated with rotation of the vertebra and rib/chest wall deformity. This can lead to poorer lung development and function which has harmful long-term effects on health related quality of life.
The timing of surgery for EOS is historically informed by the Cobb angle of the main curve (as measured on x-ray) on the understanding that children with curves beyond 75 degrees have poorer outcomes. We do not however understand the relationship between curve progression and lung function, how best to measure lung function in this population of children and whether change in lung function would be a more functional measure for deciding when surgery should take place.
A clinical study is required to investigate the best way of measuring lung function in children with EOS, how their lung function is affected and whether it may be possible to use lung function to guide the timing of treatments or surgical interventions in the future.
To help us design such a study, we will carry out a pilot study to ensure that we have the right study design, that it is achievable and that families will be able to take part.
Once completed, we will apply for funding for the primary clinical study investigating respiratory function in early onset scoliosis.
REC name
Yorkshire & The Humber - Sheffield Research Ethics Committee
REC reference
18/YH/0462
Date of REC Opinion
28 Feb 2019
REC opinion
Further Information Favourable Opinion