Resolve2-CAD
Research type
Research Study
Full title
A comparative study assessing whether inflammation resolution is impaired in women with coronary artery disease and the relationship with endothelial health using a model of systemic inflammation.
IRAS ID
334471
Contact name
Amrita Ahluwalia
Contact email
Sponsor organisation
Queen Mary University of London
Duration of Study in the UK
2 years, 11 months, 31 days
Research summary
There is a lack of understanding of how Coronary Artery Disease (CAD) – meaning the blocking or furring up of the arteries of the heart – starts and progresses in women. In both men and women CAD is the most common cause of heart attacks, which occur when the blood supply in the heart is interrupted.
Before the menopause women appear to be protected from CAD; however after the menopause that protection is lost. Also, those women who do suffer a heart attack have twice the risk of further heart attacks compared to men despite having the same treatment that works well in men. Biological differences between men and women are probably playing an important role in the way CAD develops. However, due to a lack of research there is currently little understanding of how the female body works in this area.
In this study, our aim is to better understand whether the process of resolving inflammation is impaired in peopled with coronary artery disease and whether this is related to blood vessel health. To study this, we will be using a vaccine (specifically the typhoid vaccine) to cause temporary mild inflammation within the body. This technique has been used in other studies previously and allows us to study differences in the inflammation response and blood vessel health between different groups of people. In this case we will be studying the differences between women and men with coronary artery disease, compared to those without disease. To test if the blood vessels of women and men respond differently, we will view the blood vessel in your arm using an ultrasound probe that is placed on the skin on your arm. We will also take blood samples from a vein in your arm and ask you for a saliva and urine sample.
REC name
West Midlands - Solihull Research Ethics Committee
REC reference
24/WM/0118
Date of REC Opinion
1 Aug 2024
REC opinion
Further Information Favourable Opinion