RESOLVE-COPD
Research type
Research Study
Full title
Specialised Pro-Resolving Lipid Mediators in the Resolution of Acute Exacerbations of COPD
IRAS ID
355442
Contact name
Oluwadamilola Yinka-Adebisi
Contact email
Sponsor organisation
University of Leicester
Duration of Study in the UK
2 years, 1 months, 1 days
Research summary
Respiratory disease is the third biggest cause of death globally and Chronic Obstructive Pulmonary Disease (COPD) is one the biggest causes of death within respiratory diseases, costing the NHS approximately £1.9 billion per year. People with COPD can experience "flare-ups" known as exacerbations. These flare-ups can often lead to hospital admissions and increase the chances of a patient being readmitted.
This aim of this study is to understand how a flare up of COPD affects the body's ability to "switch off" inflammation and recover. Flare-ups are associated with an overall worsening of the disease and currently, there is limited understanding on why patients don't fully recover and why frequent flare-ups lead to a decline in health.
Adults who have been admitted to hospital with a COPD flare-up will be invited to take part in the study. Patients enrolled in the main study will be given the option to donate a sputum (phlegm) sample and the patient's blood sample that was taken on admission to hospital will also be analysed.
Patients enrolled in the main study will be approached take part in the sub-study. They will give daily blood samples while they are in hospital and they will also be invited to come back for a 3-month optional follow-up visit.
Participation is voluntary and participants can choose to stop at any time without affecting their medical care. This study is organised by the University of Leicester and the findings will help to better understand how the body works to resolve inflammation after a COPD flare-up. Results will be published, but all personal information will remain anonymised so no personal information is shared.
REC name
North West - Preston Research Ethics Committee
REC reference
25/NW/0337
Date of REC Opinion
11 Nov 2025
REC opinion
Further Information Favourable Opinion