Resolution of Organ Injury in Pancreatitis (RESORP)
Research type
Research Study
Full title
Resolution of Organ Injury in Acute Pancreatitis (RESORP)
IRAS ID
178615
Contact name
Damian Mole
Contact email
Sponsor organisation
University of Edinburgh
Duration of Study in the UK
5 years, 8 months, 30 days
Research summary
Acute pancreatitis (AP) is a common disease, characterised by inflammation of the pancreas, with an overall death rate of approximately 1 in 20 patients. However, the death rate is even higher in those patients who develop problems with their organs (e.g. lungs and kidneys). We have recently discovered that this lasting negative effect of organ problems is also associated with an increased risk of death up to 10 years later, compared to those people who suffer a relatively less severe attack of AP. Why this is the case is not known. If we can discover what the problems are, we can begin to develop ways to make the overall outlook better for patients with AP.
In an initial phase, a questionnaire-based assessment of quality of life will be conducted for a previously identified cohort of patients who had an episode of AP. Those who suffered a severe episode will be invited for more in-depth testing as for the main study cohort.
In the main study, all patients who present to the Royal Infirmary with an episode of AP will be invited to undergo an assessment of organ function at the time of the initial episode and 3 and 27 months after the initial episode of AP. Study data from people who had a severe attack will be compared to data from those who had a mild attack. Participants will be invited to take part in blood tests, scans, and exercise tests over 1 or 2 days.
The study is expected to last 5 years in total to allow for participant recruitment, and will be conducted at the Royal Infirmary of Edinburgh.REC name
South East Scotland REC 01
REC reference
16/SS/0065
Date of REC Opinion
15 Apr 2016
REC opinion
Further Information Favourable Opinion