Resistance training in adults with Crohn’s disease
Research type
Research Study
Full title
Effects of a 6-month practical resistance training programme on muscle function and bone mineral density in adults with inactive or mildly active Crohn’s disease: Study protocol for a randomised controlled trial
IRAS ID
226369
Contact name
Katherine Jones
Contact email
Sponsor organisation
University of Northumbria at Newcastle
Clinicaltrials.gov Identifier
656, University of Northumbria at Newcastle
Duration of Study in the UK
2 years, 0 months, 24 days
Research summary
Exercise has been suggested to benefit Crohn’s disease (CD) patients by improving bone mineral density, muscle mass and strength, fatigue, psychological well-being, immunological response, disease activity and quality of life. Despite potential benefits, the role of exercise in CD has not been well studied and remains poorly understood. Therefore, the purpose of this study is to investigate the effects of a 6 month resistance training programme on muscle function, bone mineral density, fatigue, quality of life and disease activity in adults with CD.
Fifty adults with CD, in clinical remission or with a mildly active disease, will be recruited from a clinical population within The Newcastle Upon Tyne Hospitals NHS Foundation Trust. After initial baseline assessments participants will be randomly assigned to one of two groups: (1) a 6-month supervised and unsupervised home based resistance training programme involving 3 sessions a week for 26 weeks, plus usual care. The 12 supervised support sessions will be tapered over the 26 weeks and take place at the University of Northumbria at Newcastle sports science laboratory. Or (2) a control group who will receive usual care only.
The potential benefits of the exercise programme will involve exploring if it has had an impact on reducing inflammation (blood and stool samples), improvements in bone and muscle health (assessed using a DXA scan and biodex) and improvements in fatigue and quality of life (standardised questionnaires). All measures, except bone health (DXA scan) will be assessed at baseline, 3 and 6 months. Bone health will only be assessed at baseline and 6 months.REC name
North East - Tyne & Wear South Research Ethics Committee
REC reference
17/NE/0308
Date of REC Opinion
17 Nov 2017
REC opinion
Further Information Favourable Opinion