Resilience in Experimental Gingivitis

• Research type

  Research Study

• Full title

  FUNCTIONAL METAGENOMIC CHARACTERISATION OF RESILIENCE IN EXPERIMENTAL GINGIVITIS

• IRAS ID

  307563

• Contact name

  Richard Holliday

• Contact email

  richard.holliday@newcastle.ac.uk

• Sponsor organisation

  Newcastle University

• Duration of Study in the UK

  0 years, 11 months, 28 days

• Research summary

  This study aims to identify key microbial functions associated with resistance and resilience to gingivitis. We will run an experimental gingivitis trial, including a phase of resolution by resuming oral hygiene. Specific objectives are to: (i) establish an experimental gingivitis study, including securing ethical approval; (ii) collect clinical measurements of gingivitis and gingival margin dental plaque samples, which will then be subjected to nucleic acid extraction (DNA and RNA); (iii) send samples for metagenomics and metatranscriptomics sequencing to an external provider.
  The data collected from this study will then be analysed bioinformatically in future projects together with data from the literature [e.g. refs as above] to identify key taxa and functions that associate with oral health and resilience to experimental gingivitis. Statistical modelling will be applied to analyse longitudinal changes through the course of the study.

• REC name

  South Central - Berkshire Research Ethics Committee

• REC reference

  22/SC/0057

• Date of REC Opinion

  11 Mar 2022

• REC opinion

  Further Information Favourable Opinion