REsilience Breakthroughs in Older people UNdergoing cancer proceDures

  • Research type

    Research Study

  • Full title

    REsilience Breakthroughs in Older people UNdergoing cancer proceDures (REBOUND)



  • Contact name

    Thomas A Jackson

  • Contact email

  • Sponsor organisation

    University of Birmingham

  • Duration of Study in the UK

    3 years, 0 months, 1 days

  • Research summary

    Why and what?
    Advancements in medicine have led to increased life expectancy through improved treatment of conditions such as cancer, heart disease, and infections. However, these improvements in lifespan have not been associated with increases in healthspan (the number of years spent in good health).
    However, people age in different ways. This is often seen in how older people recover from stress events such as operations or infections, when some people recover well, whereby they take longer to recover, or never fully recover. When people do not recover well, we call this frailty. Dynamic resilience is when people recover well.
    We do not understand the biological processes between people who recover well, and those who do not. Advances in the biology of ageing means we can now test the processes associated with dynamic resilience or frailty. Excitingly, these could be targeted (so called geroprotector drugs) to make it more likely people will recover from stress events such as surgery or infections.
    We are looking to recruit 172 people aged 65 years and older who are scheduled to undergo an abdominal operation for cancer.
    We will recruit people from two NHS trusts; University Hospitals Birmingham, and Guy’s and St Thomas’ Trust (in London)
    We will ask people to join the study before their operation. We will ask them to visit for half a day and do tests of physical function and brain function and take a blood test. During the operation we will take a small sample of muscle and fat tissue.
    People will be reviewed on days 1 and 3 after their operation when we will repeat some tests and take a finger prick blood test. A more detailed follow-up at 30 days and 90 days after the operation will take place back at the hospital when we will repeat all our assessments to see if these have changed as a result of the operation.

  • REC name

    Wales REC 6

  • REC reference


  • Date of REC Opinion

    6 Mar 2024

  • REC opinion

    Further Information Favourable Opinion