RESCUE
Research type
Research Study
Full title
Rapid Evaluation and Surveillance of Critical Urgencies in Endocrinology: The RESCUE study
IRAS ID
357758
Contact name
Punith Kempegowda
Contact email
Sponsor organisation
Research Strategy and Services Division
Duration of Study in the UK
5 years, 0 months, 0 days
Research summary
Endocrine emergencies, such as severe hyponatraemia (low blood sodium) and adrenal crisis (acute hormone deficiency), are life-threatening conditions that often go under-recognised in hospitals. These emergencies can lead to long hospital stays, critical care admissions, and in some cases, preventable deaths. Although treatment guidelines exist, current care across the NHS is inconsistent, and there is no national system to monitor and improve how these emergencies are managed.
The RESCUE study (Rapid Evaluation and Surveillance of Critical Urgencies in Endocrinology) aims to change this by developing a national surveillance system. This system will collect and analyse routine hospital data to understand variations in care and outcomes for patients with severe hyponatraemia or adrenal crisis. It will also explore the real-life experiences of patients, their carers, and healthcare professionals through surveys and interviews.
RESCUE has three key components:
1. Data Collection: Gathering information from NHS hospitals about patients treated for these conditions to identify trends, risks, and gaps in care.
2. Lived Experiences: Interviewing patients, carers, and healthcare staff to understand the personal and professional challenges faced during these emergencies.
3. Education: Creating tailored training resources, including interactive online simulations (SIMBA) and visual tools (SIMBA CoMICs), to improve awareness and care among professionals and the public.
Starting with severe hyponatraemia and adrenal crisis, the study will test a model that can later be expanded to other endocrine emergencies. The ultimate goal is to reduce harm, improve the consistency and quality of care, and create a more responsive NHS system.
RESCUE will work closely with patients, healthcare providers, and support groups to ensure the findings lead to practical improvements and more informed, equitable care for people experiencing endocrine emergencies.
REC name
London - Fulham Research Ethics Committee
REC reference
26/LO/0163
Date of REC Opinion
3 Mar 2026
REC opinion
Further Information Favourable Opinion