Reproductive Endocrinology Oxford study (RepOx)
Research type
Research Study
Full title
Reproductive Endocrinology Oxford Study (RepOx)
IRAS ID
302159
Contact name
Ingrid Granne
Contact email
Sponsor organisation
University of Oxford / Clinical Trials and Research Governance
Duration of Study in the UK
8 years, 6 months, 31 days
Research summary
Polycystic ovarian syndrome (PCOS) is a condition where women have disrupted hormone levels, which lead to irregular or absent periods, and ovaries that have many small, fluid-filled sacs (known as follicles or cysts). It is the
most common hormonal disturbance causing medical problems amongst women worldwide, and somewhere between 4-15% of women between the ages of 15 to 44 years old are estimated to have the condition. PCOS is associated with a range of medical problems including heart disease, high blood pressure, diabetes, obesity, and
infertility. While pregnant women with PCOS are also more likely to suffer complications like miscarriage, pregnancy related diabetes or a liver conditions called intrahepatic cholestasis. The reason why some women develop PCOS
remain poorly understood and there are no efficient treatment options in place for the disease.
Here we propose a comprehensive program to figure out the underlying disease-causing effects of PCOS and medical complications known to be related to PCOS. The goal of our work is that the by increasing our understanding of why some women develop PCOS, we will be able to propose solutions for better and faster diagnosis, preventive measures and medicines for treating the disease and its complications.REC name
South Central - Berkshire B Research Ethics Committee
REC reference
21/SC/0271
Date of REC Opinion
7 Oct 2021
REC opinion
Further Information Favourable Opinion