Reproduction-related tissues on a cellular level

• Research type

  Research Study

• Full title

  Understanding the heterogeneity of reproduction related tissues by multi-level analyses and organoid and cell line derivation

• IRAS ID

  356429

• Contact name

  Roser Vento

• Contact email

  rv4@sanger.ac.uk

• Sponsor organisation

  Wellcome Sanger Institute

• Duration of Study in the UK

  5 years, 0 months, 1 days

• Research summary

  Menstrual fluid (MF) is a unique biological sample composed of blood, uterine lining cells, immune cells, and other components shed during menstruation.

  While often overlooked in research, it provides valuable insights into reproductive health and gynecological conditions. Only recently have advanced techniques allowed us to study MF in detail. We can now identify and analyze the different cell types present in MF using single-cell transcriptomics, helping us understand their roles in health and disease. This technique analyses individual cells in the tissue by looking at genes that the cell expresses.
  Since MF naturally reflects changes in the uterus, studying it can offer a non-invasive way to detect gynecological disorders such as endometriosis and adenomyosis.

  In our study, we will collect menstrual fluid samples from both healthy participants and individuals with gynecological disorders. By comparing these samples, we aim to determine which cells make up menstrual fluid and how they differ in health and disease. Additionally, we will grow some of these cells in the lab, creating valuable models for future research and drug testing. In order to understand how the composition of MF correlates with other related tissues in the body (e.g. the uterus), we will also collect surgical samples from participants undergoing surgeries.

  Eligible participants include individuals who menstruate regularly, including those diagnosed with gynecological conditions. Samples will be collected at the Wellcome Sanger Institute and other sites (clinics and hospitals),
  and the study will run for 5 years.

  Our research has the potential to revolutionize the way we diagnose and treat gynecological disorders, ultimately improving women's health worldwide.
  

• REC name

  London - Stanmore Research Ethics Committee

• REC reference

  25/LO/0357

• Date of REC Opinion

  8 Jul 2025

• REC opinion

  Further Information Favourable Opinion