REPRIEVED
Research type
Research Study
Full title
REvascularisation for heart failure with PReserved ejection fraction and Ischaemia: EValuation of Efficacy and mechanistic Description (REPRIEVED)
IRAS ID
330189
Contact name
Matthew Ryan
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
4 years, 11 months, 31 days
Research summary
HFpEF (heart failure with preserved ejection fraction) is a serious medical condition where the heart muscle stiffens and is unable to properly pump blood around the body. There are very few treatments for HFpEF. Half of people with HFpEF have coronary artery disease, blockages in the blood vessels which supply the heart. These blockages are thought to be the cause of heart failure. Stents are small metal tubes used to unblock arteries in a keyhole operation so that blood can flow normally. Research shows that they are a good treatment for heart attacks and angina in patients without heart failure. We think that stents will help people with HFpEF and coronary artery disease but need research to prove this. The REPRIEVED trial aims to find out if treating people with HFpEF and coronary artery disease with stents improves their quality of life and the blood supply to their heart.
We will ask 350 people with HFpEF and coronary artery disease to take part. They will fill out questionnaires about their health, have blood tests, ECG tracings and two scans of their heart. The person taking part will come to hospital for an angiogram. During the same procedure, half of the people taking part will receive stents, and half will not. They will not know whether they have had stents. This helps us to know that any improvements in their quality of life are not just related to how they feel about the stenting treatment.
After six months they will fill in questionnaires, have another scan, blood test and ECG tracing to measure any changes to find out if stents work. We will work with people and organisations who have expertise in improving access and equality in research as women and people from ethnic minorities are the main groups affected by HFpEF, but are currently underrepresented in HFpEF research. The whole project will last five years.
REC name
London - Riverside Research Ethics Committee
REC reference
25/LO/0277
Date of REC Opinion
6 May 2025
REC opinion
Further Information Favourable Opinion