REPEM- Antibiotic registration study in febrile children
Research type
Research Study
Full title
Antibiotic prescription in febrile children: impact of clinical profile and cultural background
IRAS ID
173631
Contact name
Rianne Oostenbrink
Contact email
Sponsor organisation
Erasmus Medical Centre
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Fever is the most frequent reason for a child to attend the pediatric emergency department. The majority suffers from selflimiting illness, with serious bacterial infections present ranging from 5% (intermediate) to 30% (high prevalence
setting). Current guidelines state that there is no indication for oral antibiotics in children with fever and unestablished diagnosis. Nevertheless, we still have high antibiotic prescription rates in febrile children and often broad spectrum
antibiotics are used. We need a study to get insight in when and why clinicians decide to antibiotic prescription in febrile children and what determinants contribute to their decision. This insight will add to improve targeted antibiotic prescription in the febrile child. We will perform an observational study in about 20 emergency care centres in Europe, and register data of febrile children visiting the emergency care.
The primary aim is to create a registry on antibiotic prescription in febrile children attending emergency departments in Europe, with focus on clinical signs and symptoms and therapeutic data. The main research question is to describe the current prescribing antibiotic behavior in febrile children at the emergence care, with specific interest in the variability among countries and clinical conditions. This will include
description of overall antibiotic prescription, broad versus narrow antibiotic use, antibiotic dosage and duration of therapy.REC name
West of Scotland REC 3
REC reference
15/WS/0031
Date of REC Opinion
11 Feb 2015
REC opinion
Favourable Opinion