REPAIR
Research type
Research Study
Full title
Reframing Endometrial Physiology by Advanced Integrated Research
IRAS ID
362221
Contact name
Ying Cheong
Contact email
Sponsor organisation
University Hospital Southampton NHS Foundation Trust
Duration of Study in the UK
4 years, 0 months, 1 days
Research summary
Heavy menstrual bleeding (HMB) affects around 1 in 3 women of reproductive age and can significantly impact physical, emotional, and social wellbeing. Despite its prevalence, HMB remains underdiagnosed and poorly understood. This is partly because current assessments rely on self-reported symptoms and specialist investigations that are not widely accessible or standardised.
The REPAIR study (Reframing Endometrial Physiology by Advanced Integrated Research) aims to better understand the biological and physiological mechanisms that cause HMB and to develop simpler, non-invasive tools for its diagnosis.
This application pertains only to the UK arm of the study, which will be delivered at the University of Southampton in partnership (host) with University Hospital Southampton NHS Foundation Trust (UHS, Sponsor). Participants with and without HMB will be recruited. Each participant will complete symptom questionnaires and provide biological samples including blood, menstrual fluid, and an endometrial biopsy. They will also undergo a pelvic MRI scan and use a small wearable sensor that records uterine electrical activity at home and in clinic, similar to a heart monitor.
By combining wearable data, imaging, and biological samples, the study will identify measurable patterns—or “vital signs”—that distinguish between healthy and abnormal menstrual physiology. These findings may inform the development of future low-cost, user-friendly diagnostic tools that can be used in community or home settings.
This is a non-interventional, observational study and forms part of a wider international research programme. However, this ethics application covers only the UK site. The REPAIR study has the potential to reduce diagnostic delays, personalise treatment, and improve care for people experiencing heavy menstrual bleeding.
REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
25/YH/0222
Date of REC Opinion
9 Dec 2025
REC opinion
Further Information Favourable Opinion