Renal recovery post sepsis induced Acute Kidney Injury in ICU
Research type
Research Study
Full title
Exploring renal recovery post sepsis induced AKI in critical care patients to improve treatment and recovery.
IRAS ID
274239
Contact name
Shondipon Laha
Contact email
Sponsor organisation
Lancashire Teaching Hospitals NHS Foundation Trust
Duration of Study in the UK
0 years, 6 months, 0 days
Research summary
Title: Exploring renal recovery post sepsis induced AKI in critical care patients to improve treatment and recovery.
Sepsis/septic shock account for 37% of intensive care admissions with the most common complication being acute kidney injury (AKI). Septic AKI is understood to have a separate pathophysiology to non-septic AKI. Although by hospital discharge renal function recovers in most, risk of death is increased compared to other forms of AKI over the 2 years post discharge. Furthermore, recent studies have shown that acute kidney injury has long term impact on both renal function and mortality. Septic AKI is believed to have a distinct pathophysiology from non-septic AKI and studies specific to this have yet to be conducted. There is evidence that septic AKI has an immediate effect on mortality, but nothing has been conducted regarding long term renal recovery. Gaining a greater understanding of the impact that septic AKI has on long term outcomes, both in terms of renal recovery and mortality will have a significant impact on stratification of treatment, both during admission and post discharge.This retrospective observational study would look at adult patients, without chronic kidney disease, admitted to the Royal Preston Hospital intensive care unit in the years 2015 and 2016 who developed a septic AKI. In order to be eligible the patients will need to have records of renal function blood tests taken 6 months, 1 year and 2 years post discharge available on the hospital computer system. Clinical details in regards to their initial hospital admission and information on co-morbidities available on the hospital system will also be noted. The medical notes will be only accessed by an member of the immediate medical team who looks at patients notes as part of their day to day job and data will be anonymised on collection.
REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
20/LO/0267
Date of REC Opinion
21 Feb 2020
REC opinion
Favourable Opinion