Renal Ischaemia reperfusion injury
Research type
Research Study
Full title
Study of renal ischaemia-reperfusion injury and its amelioration
IRAS ID
190379
Contact name
Kourosh Saeb-Parsy
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
Kidney transplantation is the optimal treatment for selected patients with end-stage renal failure (ESRF) and is associated with improved quality of life, longer patient survival and reduced costs compared to remaining on dialysis. Despite vast advances in the area of transplantation, the number of available kidneys cannot meet the demands of the ever growing waiting list for kidney transplantation. Many donor kidneys are discarded due to perceived suboptimal quality or risk of poor function after transplantation, vastly contributing to the lack of available kidneys for transplantation. This has necessitated further understanding of the damage of kidneys during the retrieval process, its amelioration, as well as investigation of therapeutic strategies. This study will use declined human kidneys to study the mechanisms of ischaemia reperfusion injury and how it can be ameliorated using novel therapeutic interventions. It is anticipated that this information will help develop evidence-based guidelines for the suitability of kidneys for transplantation and ultimately increase the number of kidneys transplanted and their outcomes. The tissue from the same kidneys will also be used to study normal and pathological processes in the kidney, thus maximising the translational and clinically important data that is generated from the discarded tissue.
REC name
North East - Newcastle & North Tyneside 2 Research Ethics Committee
REC reference
15/NE/0408
Date of REC Opinion
27 Nov 2015
REC opinion
Favourable Opinion