Renal dysfunction in patients with muscle wasting after critical care
Research type
Research Study
Full title
Skeletal Muscle Wasting and Renal Dysfunction in Patients After Critical Illness and Major Trauma - Outcomes Study (KRATOS)
IRAS ID
236569
Contact name
John Prowle
Contact email
Sponsor organisation
Queen Mary, University of London
Duration of Study in the UK
1 years, 8 months, 1 days
Research summary
More people than ever are surviving life-threatening illnesses such as major trauma. However, until now doctors and researchers have focused more on improving short term survival than on the serious, long-term complications experienced by survivors of critical illness. In response, the National Institute for Health and Care Excellence (NICE) and patient-clinician partnerships such as the James Lind Alliance, have now prioritised research into the diagnosis, follow-up and treatment of critical care survivors.
Development of chronic kidney disease and persistent muscle weakness are two commonly encountered complications which significantly impact long-term health and wellbeing after critical illness. Worsening of kidney function strongly predisposes to development of heart disease, premature death or need for long-term dialysis. Similarly, the muscle wasting experienced by almost all survivors of critical illness can result in persistent, life changing limitations to daily living, inability to work and decreased quality of life. Importantly, the human and economic consequences of critical illness may be particularly profound in major trauma victims who are often young and previously healthy. In this project, we aim to simultaneously measure changes in kidney function and muscle mass after critical illness allowing us to understand how these processes interact in affecting longer-term patient outcomes.
We will recruit 62 patients, 31 admitted to intensive care after major trauma and 31 admitted for other reasons. We will use complementary methods to accurately monitor muscle mass and kidney function. Six months after discharge from hospital, we will assess patient's ability to manage their daily activities and quality of life, and will measure muscle mass, strength and kidney function. The study will be performed at the Royal London Hospital, an internationally renowned centre for critical care and trauma research. The Patient/Public Advisors for Injury Research have advised on patient-engagement, reviewed our study protocol and will assist with dissemination of results.
REC name
Wales REC 6
REC reference
18/WA/0304
Date of REC Opinion
12 Oct 2018
REC opinion
Further Information Favourable Opinion