Renal Bone Quality Study
Research type
Research Study
Full title
Understanding bone material properties in advanced chronic kidney disease patients with renal osteodystrophy (BMP-CKD study)
IRAS ID
319173
Contact name
Syazrah Salam
Contact email
Sponsor organisation
Sheffield Teaching Hospitals NHS Foundation Trust
Duration of Study in the UK
0 years, 11 months, 30 days
Research summary
Fracture risk is four times higher in advanced chronic kidney disease (CKD) patients compared to non-CKD and this is associated with high mortality. Low bone quantity does not fully explain this high fracture risk, suggesting that impaired bone quality plays a major role. These patients have a spectrum of abnormal bone turnover, mineralization and microstructure called renal osteodystrophy (ROD). ROD may affect bone quality, such as mechanical properties, which has been demonstrated in animal experiments but not well studied in humans.
This study aims to assess the difference in bone quality between advanced CKD and healthy controls. The relationship between bone turnover and microstructure with bone stiffness and hardness will also be assessed. Ten advanced CKD patients and ten healthy controls will undergo a blood test for bone turnover assessment and bone biopsy. Bone specimens will undergo micro computed tomography (microCT) to assess microstructure and nanoindentation to assess bone stiffness and hardness.REC name
East Midlands - Nottingham 2 Research Ethics Committee
REC reference
22/EM/0267
Date of REC Opinion
8 Dec 2022
REC opinion
Favourable Opinion