Remote ischaemic conditioning following hip fracture (RIC-FRACTURE)
Research type
Research Study
Full title
Remote ischaemic conditioning following hip fracture (RIC-FRACTURE)
IRAS ID
339889
Contact name
Ali ALI
Contact email
Sponsor organisation
Sheffield Teaching Hospitals
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 0 months, 5 days
Research summary
Hip fracture affects 70,000 people in the UK and costs an estimated £1.1 billion per year to the NHS. Early surgical repair has been shown to improve patient outcomes however morbidity and mortality remains extremely high due to the occurrence of complications such as infection, cardiovascular events, falls and thromboses.
Remote ischaemic conditioning (RIC) is the treatment whereby brief episodes of
blood flow occlusion are applied to a arm or a leg using a blood pressure cuff. This is performed for periods that avoid physical injury to the limbs, but trigger changes in the body such as improved blood flow to organs and reduced levels of inflammation. We want to know if this may be helpful in improving outcomes after hip fracture.First we want to know if it is safe, tolerable and feasible to perform this treatment after hip fracture. To do this we will conduct a feasibility study in Sheffield Teaching Hospitals Orthopaedic department. We will recruit 12 people who have suffered hip fracture to undergo daily RIC for 2 weeks (10 sessions, 5 days a week). We will collect information on safety and tolerability of the treatment for the intervention period, and the feasibility of recruiting patients to a clinical trial of RIC in hip fracture. We will also collect clinical outcomes at discharge and at 3 months following discharge.
If RIC is safe and tolerable, and it appears feasible to recruit such patients then we will look to undertake a larger trial of this treatment to improve clinical outcomes for hip fracture.
REC name
Wales REC 7
REC reference
24/WA/0152
Date of REC Opinion
28 May 2024
REC opinion
Favourable Opinion