Remote biomarkers in MS
Research type
Research Study
Full title
The utility of remote sampling biomarkers of disease activity in patients with multiple sclerosis
IRAS ID
299941
Contact name
Ruth Dobson
Contact email
Sponsor organisation
Queen Mary University London
Duration of Study in the UK
1 years, 6 months, 22 days
Research summary
This project will study the use of biomarkers that can be measured on a fingerprick blood sample in people with MS. CSF neurofilament light (NfL) is routinely used as a marker of disease activity, and there is increasing experience with plasma NfL. However, the variation in plasma NfL over time in a stable population is not well established.
This study will compare NfL in CSF, plasma and fingerprick sample at baseline, where patients are having CSF NfL measured as part of routine clinical care. Participants will then be asked to provide fingerprick samples every 2 months over a 6 month period along with a patient reported measure of MS impact (MSIS-29) and disability score (webEDSS). All of these assessments will be done by the patient in their home and posted to researchers.
With this information, researchers will be able to better understand the relationship between CSF, plasma and fingerprick levels of NfL, and understand how NfL changes over time.
REC name
North East - Newcastle & North Tyneside 1 Research Ethics Committee
REC reference
21/NE/0153
Date of REC Opinion
4 Aug 2021
REC opinion
Favourable Opinion